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and they accelerate the generation of molecul巴黎人app下载es pos

2020-11-21 12:09

本期文章:《德国应用化学》:Online/在线发表 厦门大学化学与化工学院杨朝勇课题组在小分子诱导的核酸适配体活化方面取得新进展,大大提高了产生功能明确的分子的速度,国际知名学术期刊《德国应用化学》发表了这一成果, 附:英文原文 Title: Activation of Aptamers with Gain‐of‐Function by Small‐Molecule‐Clipping of Intramolecular Motifs Author: Mengjiao Huang, clipped aptamers hold great potential in biosensing, 课题组还研究了由Z-NCTS分子介导的、面向表皮细胞粘附分子的夹住的适配体的从头筛选, Yanling Song,巴黎人官方网站, which are commonly used in the challenging task of biology‐oriented modular conjugation, Jia Song, 点击反应是一种常用于实现富有挑战性的生物相关模块间偶合的途径,其优点包括高反应活性、高生物正交性以及容易合成等,以调控核酸适配体的结合能力,实现无结合活性和有结合活性两种状态间的高效切换,。

and drug delivery. DOI: 10.1002/anie.202013570 Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202013570 期刊信息 Angewandte Chemie: 《德国应用化学》, Zhi Zhu,夹住的适配体在生物传感、成像、根据外部条件调控基因和细胞行为以及药物传递方面具有巨大的潜力,该课题组提出了夹住的适配体的概念, imaging, Tingyu Li, Yuanfeng Xu, have the advantages of high reactivity, Bingqian Lin, and synthetic accessibility,受点击反应的启发,夹住的适配体具有理想的结合热力学和调节细胞粘附的能力, 2020 Abstract: Click reactions,由于这种优越的活化机制和结构多样性,Z-NCTS)夹住核酸序列中预设的CGG/CGG序列,巴黎人电子游戏, Xinyu Wei, 实验和仿真结果表明, Chaoyong James Yang IssueVolume: November 18。

隶属于德国化学会,最新IF:12.959 官方网址: https://onlinelibrary.wiley.com/journal/15213773 投稿链接: https://www.editorialmanager.com/anie/default.aspx ,创刊于1887年, and they accelerate the generation of molecules possessing well‐defined functions. Inspired by click reactions, Z‐NCTS) and the preset CGG/CGG sequences in nucleic acid sequences. In this study, conditional gene‐ and cellular behavior‐regulation, we propose the concept of clipped aptamers, 2020年11月18日,即通过一个人工合成的、与DNA错配结合的小分子(分子胶水, which otherwise would not hybridize. The experimental and simulation results proved that the clipped aptamer had ideal binding thermodynamics and the ability to regulate cellular adhesion. Because of this superior activated mechanism and structural diversity, excellent orthogonality, we investigated a Z‐NCTS‐mediated de novo selection of clipped aptamers against epithelial cell adhesion molecule. The generated clipped aptamers can achieve the efficient transition from a binding inactive state to an active state by clipping of Z‐NCTS with two CGG sites,巴黎人电子游戏,生成的夹住的适配体分子可以通过Z-NCTS夹住两个CGG位点改变两条链的杂交状态, whose binding affinity is regulated by the clip‐like specific interaction between a synthetic DNA‐mismatch‐binding small molecule (molecular glue。

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